In the OR I saw a partial nephrectomy on a relatively young
patient. Other than renal cell carcinoma the patient had several other
comorbidities, including kidney stones and kidney failure. The surgeon picked
out on the order 10 kidney stones the size of large olive pits. Both the
surgeon and the nurses seemed surprised by their large size.
After meeting with Dr Bander again he expressed and interest
in examining the effects of Epithelial to Mesenchymal transition on the PSMA
expression of prostate cancer cells, initially in the cell lines that they are
growing. The idea is to use TGF-beta to induce EMT and then quantify some key
indicators of EMT and the PSMA expression on treated and untreated cells.
Despite the fact that our first patient in the clinical trial
should have arrived last week we are still being held up by the legal
department. We will thus have to cancel and move on to the second patient.
However, he isn’t scheduled for another three weeks, giving me very little time
to do anything with my project. I am also trying to set up meetings with a
number of different faculty members to discuss alternatives.
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